Rapid analysis of methamphetamine in hair by micropulverized extraction and microchip-based competitive elisa.

Rapid analysis of methamphetamine in hair by micropulverized extraction and microchip-based competitive ELISA. Forensic Sci Int. 2008 Dec 22; Authors: Miyaguchi H, Takahashi H, Ohashi T, Mawatari K, Iwata YT, Inoue H, Kitamori T An automated full-range quantitation method for identifying d-methamphetamine in human hair using a microchip-based ELISA system (microELISA) in combination with a micropulverized extraction method for sample preparation has been developed. An antibody and a peroxidase-linked methamphetamine, both are commercially available, were used for the competitive ELISA assay. Method validation was carried out using doped hair samples, and segmental analyses of real-case specimens were carried out by both microELISA and LC/MS/MS to verify the reliability and appl...

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