Case report: Etizolam and its major metabolites in two unnatural death cases.
Forensic Sci Int. 2008 Oct 29;
Authors: Nakamae T, Shinozuka T, Sasaki C, Ogamo A, Murakami-Hashimoto C, Irie W, Terada M, Nakamura S, Furukawa M, Kurihara K
A simultaneous analytical method for etizolam and its main metabolites (alpha-hydroxyetizolam and 8-hydroxyetizolam) in whole blood was developed using solid-phase extraction, TMS derivatization and ion trap gas chromatography tandem mass spectrometry (GC-MS/MS). Separation of etizolam, TMS derivatives of alpha-hydroxyetizolam and 8-hydroxyetizolam and fludiazepam as internal standard was performed within about 17min. The inter-day precision evaluated at the concentration of 50ng/mL etizolam, alpha-hydroxyetizolam and 8-hydroxyetizolam was evalua...