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Abstract We have determined drug/metabolite concentrations and ratios of methadone (METH) to two of its metabolites (EDDP, 2-ethylidene-1,
5-dimethyl-3, 3-diphenylpyrrolidine; and EMDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline) in postmortem peripheral blood and
liver tissue by liquid chromatography/tandem mass spectrometry. The assays employed deuterated internal standards and multiple
reaction monitoring (MRM) techniques. The assay linear range was 0.01–2.0 mg/l for each analyte. METH, EDDP, and EMDP were
determined in liver and peripheral blood from 46 methadone-positive cases. METH and EDDP were detected in all specimens, whether
blood or liver. EMDP was detected, only in liver, and only 17 cases, at concentrations much lower than those of EDDP. Concentrations
of METH and EDDP in blood and liver from EMDP-positive cases were in ranges higher than, but overlapping with, concentrations
in blood and liver from EMDP-negative cases. These data suggest that although METH is readily demethylated and cyclized to
EDDP, in vivo, conversion to EMDP may be less efficient and its accumulation in postmortem tissues may be highly individual.
Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12024-008-9039-7Authors
Terry J. Danielson, Harris County Medical Examiner 1885 Old Spanish Trail Houston TX 77054 USAAshraf Mozayani, Harris County Medical Examiner 1885 Old Spanish Trail Houston TX 77054 USALuis A. Sanchez, Harris County Medical Examiner 1885 Old Spanish Trail Houston TX 77054 USA
Journal Forensic Science, Medicine, and PathologyOnline ISSN 1556-2891Print ISSN 1547-769X (Source: Forensic Science, Medicine, and Pathology)
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Establishing correlation of footprints with body weight-Forensic aspects.
Forensic Sci Int. 2008 May 30;
Authors: Krishan K
Analysis of footprints can reveal very important clues which can be used as forensic evidence in crime scene investigation. Apart from giving idea about the bare foot morphology and individualistic characteristics, the footprints are also indicative of the body size of the person. The present study is an attempt to establish the correlation between footprints and body weight of individuals. The sample for the present study consists of 50 male subjects ranging in age from 18 to 30 years. The subjects belonging to Gujjar caste were randomly taken from a village near Chandigarh city in North India. Three kinds of bilateral footprints were taken from each subject. First, the footprints with the subject's normal weight were taken, the footprints were taken when the subject holds 5kg weight in his hands, then the footprints were taken when the subject holds 20kg weight in his hands. In this way, the present study analyses 300 bilateral footprints obtained from 50 individuals. Nine measurements were taken on each footprint using precise and defined landmarks. The measurements of these three kinds of footprints were compared with each other and t-test was employed to see the significant variation. Some of the measurements of the footprints were altered significantly when the subject was subjected to 20kg weight. However, there is no significant change when the subject holds 5kg weight in his hands. Body weight was also estimated using regression method from the measurements of these three kinds of footprints. The utility of the study in offences like sexual assault, homicide, theft, burglary, mugging, stealing, shoplifting, dacoity, etc. has been discussed.
PMID: 18515026 [PubMed - as supplied by publisher]
(Source: Forensic Science International)
«al nord il 60-70% dei crimini commessi dagli immigrati clandestini«In Italia c'è un indulto quotidiano»Manganelli: ci troviamo in una situazione di «indulto quotidiano in cui tutti parlano, ma nessuno faROMA - La certezza della pena non esiste pi...
Page: 114DOI: 10.1097/PAF.0b013e318174f0a9Authors: Hanzlick, Randy MD *+; Prahlow, Joseph A. MD ++[S]; Denton, Scott MD [P]; Jentzen, Jeffrey MD [//]; Quinton, Reade MD **; Sathyavagiswaran, Lakshmanan MD ++; Utley, Suzanne MD ++++ (Source: The American Journal of Forensic Medicine and Pathology)
Page: 123DOI: 10.1097/PAF.0b013e318173f067Authors: Ripple, Mary G. MD *; Grant, Jami R. PhD +; Mealey, Joan BS +; Fowler, David R. MB, ChB, MMed(Path) * (Source: The American Journal of Forensic Medicine and Pathology)
