Abstract Our laboratory received hair samples of three children after alleged exposure to Feminax tablets, which contain scopolamine
as an ingredient; it was regarded as an offense by the police because a woman had repeatedly beaten her children and forced
each of them to take four to ten Feminax tablets per day. Neither blood nor urine samples of the children had been obtained
at the time of the alleged offense. Thus, hair strands were obtained from the children as specimens in acquiring evidence
of the offense. We conducted segmental hair analysis of scopolamine using ultra performance liquid chromatography (UPLC)-tandem
mass spectrometry (MS-MS), which is highly sensitive and specific, and enabled the measurements of scopolamine at subpicogram-permilligram
levels present in the hair segments. By our UPLC-MS-MS analysis, it was found that the concentrations in the hair segments
ranged from 0.3 to 1.1 pg/mg and that exposure to scopolamine had continued for at least several months prior to the hair
sampling for all children. Because of our scientific evidence, the mother pleaded guilty to the offense against her children
despite her denial at the outset of the investigation.
Content TypeJournal Article
JournalForensic ToxicologyOnline ISSN 1860-8973Print ISSN 1860-8965 (Source: Forensic Toxicology)